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JBC Podcasts icon Atomic Structure of GRK5 and Crystal Structure of the GRK5CCG215022 Complex

In this week’s episode of the JBC Paper of the Week podcast, we had the unique opportunity to interview the authors of two papers concurrently publishing structures of G-protein–coupled receptor kinase 5 (GRK5). John Tesmer and Jeff Benovic, along with their research groups, independently solved the GRK5 crystal structure.

SIGNAL TRANSDUCTION
IN PRESS

Jeffrey R. Erickson, C. Blake Nichols, Hitoshi Uchinoumi, Matthew L. Stein, Julie Bossuyt, Donald M. Bers
First Published on Aug 27, 2015
Andrew David James, Waseema Patel, Zohra Butt, Magretta Adiamah, Raga Dakhel, Ayse Latif, Carolina Uggenti, Eileithyia Swanton, Hiromi Imamura, Ajith Kumar Siriwardena, Jason Irving Edward Bruce
First Published on Aug 20, 2015
Zhongdong Hu, Ying Wang, Fuqiang Huang, Rongrong Chen, Chunjia Li, Fang Wang, June Goto, David J. Kwiatkowski, Joanna Wdzieczak-Bakala, Pengfei Tu, Jianmiao Liu, Xiaojun Zha, Hongbing Zhang
First Published on Aug 20, 2015
Evgenia Rouka, Philip C. Simister, Melanie Janning, Joerg Kumbrink, Tassos Konstantinou, João R. C. Muniz, Dhira Joshi, Nicola O'Reilly, Rudolf Volkmer, Brigitte Ritter, Stefan Knapp, Frank von Delft, Kathrin H. Kirsch, Stephan M. Feller
First Published on Aug 20, 2015
Evgenia Rouka, Philip C. Simister, Melanie Janning, Joerg Kumbrink, Tassos Konstantinou, João R. C. Muniz, Dhira Joshi, Nicola O'Reilly, Rudolf Volkmer, Brigitte Ritter, Stefan Knapp, Frank von Delft, Kathrin H. Kirsch, Stephan M. Feller
First Published on Aug 20, 2015
Peter D. Simpson, Betty A. Eipper, Maximiliano J. Katz, Lautaro Gándara, Pablo Wappner, Roman Fischer, Emma J. Hodson, Peter J. Ratcliffe, Norma Masson
First Published on Aug 19, 2015
Junchao Cai, Jingjing Zhao, Nu Zhang, Xiaonan Xu, Rong Li, Yang Yi, Lishan Fang, Le Zhang, Mengfeng Li, Jueheng Wu, Heng Zhang
First Published on Aug 18, 2015
Deborah Balzano, Mohamad-Ali Fawal, Jose V. Velazquez, Clara M. Santiveri, Joshua Yang, Joaquin Pastor, Ramon Campos-Olivas, Nabil Djouder, Daniel Lietha
First Published on Aug 18, 2015

Best of 2014

Lixia Jia, Mariangela Chisari, Mohammad H. Maktabi, Courtney Sobieski, Hao Zhou, Aaron M. Konopko, Brent R. Martin, Steven J. Mennerick, Kendall J. Blumer
February 28, 2014 The Journal of Biological Chemistry, 289, 6249-6257.

PAPERS OF THE WEEK

REPORTS

Katy J. Petherick, Owen J. L. Conway, Chido Mpamhanga, Simon A. Osborne, Ahmad Kamal, Barbara Saxty, Ian G. Ganley
First Published on Apr 01, 2015
Aaron C. Overland, Paul A. Insel
First Published on Mar 10, 2015

CLASSICS

The Barnard team used a radiolabeled benzodiazepine for detecting the GABA 
receptors after the purification process.
First Published on Nov 23, 2012
Yale Nemerson
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jun 24, 2011
Edmond H. Fischer
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jan 14, 2011
Yasutomi Nishizuka
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Oct 22, 2010
Earl W. Davie
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Nov 24, 2006
Martin Rodbell. Photo courtesy of the National Library of Medicine.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jul 21, 2006
Line art representation of a quill pen. Photo credit: Wikimedia Commons: 
http://commons.wikimedia.org/wiki/File:Quill_%28PSF%29.png.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Apr 21, 2006
Sune Karl Bergström. Photo courtesy of the National Library of Medicine.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Feb 25, 2006
Alfred Gilman at the 1994 Nobel Prize awards.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Oct 28, 2005
Photo of Edwin G. Krebs, courtesy of the National Library of Medicine.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Oct 21, 2005
Photo courtesy of the National Library of Medicine.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Oct 14, 2005
Lowell and Mabel Hokin. Photo courtesy of Nature Publishing Group.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jul 22, 2005
Christian A. Herter. Photo courtesy of the National Library of
Medicine.
Robert D. Simoni, Robert L. Hill, Martha Vaughan
First Published on Apr 19, 2002
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REFLECTIONS

*Jackie Corbin playing football for Tennessee Tech in 1961.*
Jackie Corbin
First Published on Dec 11, 2014
*Massimo Aloisi (courtesy of Alfredo Margreth).*
Ernesto Carafoli
First Published on Jul 08, 2013
In 1972, Roy Vagelos (/left/) was elected to the National Academy of 
Sciences.
Philip W. Majerus
First Published on Dec 17, 2010
*Ed Krebs (/left/) and Eddy Fischer (/right/) in 1992 upon hearing that they 
have been awarded the Nobel Prize for Physiology or Medicine.*
Philip Cohen
First Published on Jun 10, 2009
*General schematic representation of the elongation cycle of a translating 
ribosome.* Each cycle results in (i) elongation of a growing peptide chain by 
one amino acid residue (formation of one peptide bond), (ii) hydrolysis of 
two GTP molecules, (iii) entry of one molecule of aminoacyl (/Aa/)-tRNA into 
intersubunit channel, (iv) exit of one molecule of deacylated tRNA from the 
intersubunit channel, and (v) movement of mRNA chain by three nucleotides 
toward the 3′-end. Here, as well as in Figs. 3–5, ribosomal particles are 
shown in the orientation in which the small subunit (/yellow/) is on the top 
and the large subunit (/red/) is on the bottom. The head of the small subunit 
and the central protuberance of the large subunit are facing the viewer, with 
the L7/L12 stalk of the large subunit directed to the left. In this 
orientation, the bound L-like tRNAs must face the viewer by their external 
angles (“elbows”), as in reality they are facing the head of the small 
subunit; however, here, as well as in Figs. 3–5, for the sake of better 
discerning between the A and P site tRNAs, the external angles of their 
symbolical depictions (/green/) are shown to be drawn apart. The intersubunit 
channel accommodating the mRNA and tRNAs is traced by /dotted lines/. A and P 
are the tRNA-binding sites on the small subunit, and /a/, /p/, and /e/ are 
the binding sites for their 3′ termini, either acylated or deacylated, on 
the large subunit. (For the sake of better clarity, the subsites on the small 
subunit are designated by capital letters, A and P, as originally proposed 
and usually accepted (59, 94), whereas the large subunit subsites, which are 
localized within a small area of the PTC and nearby, are designated by 
lowercase italicized letters, /a/ and /p/, as proposed elsewhere (92).)
Alexander S. Spirin
First Published on May 05, 2009
Photo courtesy of Vanderbilt University.
Stanley Cohen
First Published on Aug 12, 2008
John H. Exton
First Published on Mar 31, 2008
Prospect of grant request being funded in relation to the originality of the 
research proposal.
Howard K. Schachman
First Published on Feb 03, 2006
Photo credit: Fran Pollner/NIH Catalyst, July-August 1997.
Ira Pastan
First Published on Mar 29, 2005
*Professor Hans Neurath (1909-2002).*
Earl W. Davie
First Published on Oct 21, 2003
John Jacob Abel
Joseph S. Fruton
First Published on Apr 17, 2002
The bicyclic cascade that regulates GS activity. Interrelationship between 
the cyclic interconversion of the regulatory protein between uridylylated 
(PII(UMP)4) and unuridylylated (PII) forms, and the cyclic interconversion of 
GS between adenylylated (GS(AMP)12) and unadenylylated forms, and the 
reciprocal control of these interconversions by l-glutamine (Gln) and 
α-ketoglutarate (α-KG). ATa and ATd denote the adenylylation and 
deadenylylation sites of adenylyltransferase, respectively; UTd and UTudenote 
the deuridylylation and uridylylation sites of uridylyltransferase, 
respectively. Reprinted with permission from Rhee et al. (Rhee, S. G., 
Chock, P. B., and Stadtman, E. R. (1985) in The Enzymology of 
Post-translational Modification ofProteins (Freedman, P. B., and Hawkins, 
H. C., eds) Vol. 2, pp. 273–297, Academic Press, New York).
Earl R. Stadtman
First Published on Oct 03, 2001
The bicyclic cascade that regulates GS activity. Interrelationship between 
the cyclic interconversion of the regulatory protein between uridylylated 
(PII(UMP)4) and unuridylylated (PII) forms, and the cyclic interconversion of 
GS between adenylylated (GS(AMP)12) and unadenylylated forms, and the 
reciprocal control of these interconversions by l-glutamine (Gln) and 
α-ketoglutarate (α-KG). ATa and ATd denote the adenylylation and 
deadenylylation sites of adenylyltransferase, respectively; UTd and UTudenote 
the deuridylylation and uridylylation sites of uridylyltransferase, 
respectively. Reprinted with permission from Rhee et al. (Rhee, S. G., 
Chock, P. B., and Stadtman, E. R. (1985) in The Enzymology of 
Post-translational Modification ofProteins (Freedman, P. B., and Hawkins, 
H. C., eds) Vol. 2, pp. 273–297, Academic Press, New York).
Earl R. Stadtman
First Published on Oct 03, 2001
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