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SIGNAL TRANSDUCTION
AT THE JBC

JBC Podcasts iconAhmed ChadliJBC News Podcast: Gedunin, Hsp90 and p23
In this podcast, we hear an interview with Ahmed Chadli at the Georgia Regents University, who talks about his Paper of the Week, Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis. The paper delves into the molecular mechanism of action of a naturally occurring product that is found in the neem tree, an Indian medicinal plant.Click on the photo of Ahmed Chadli.
John KyriakisThe Journal of Biological Chemistry has maintained a long and proud tradition of publishing cutting edge papers in the field signal transduction — a legacy that dates back to the publication of Krebs and Fisher’s studies of phosphorylase kinase in 1955 and Earl Sutherland’s work on cyclic-AMP in 1958.
 
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SIGNAL TRANSDUCTION
IN PRESS

Direct role for the replication protein Treslin (Ticrr) in the ATR-mediated checkpoint response
Bachar H. Hassan, Laura A. Lindsey-Boltz, Michael G. Kemp, Aziz Sancar
First Published on May 22, 2013
The SEC14 and spectrin domains 1 (Sestd1) and Dapper antagonist of catenin 1 (Dact1) scaffold proteins cooperatively regulate the Van Gogh-like 2 (Vangl2) 4-pass transmembrane protein and planar cell polarity (PCP) pathway during embryonic development in mice
XiaoYong Yang, Benjamin N.R. Cheyette
First Published on May 21, 2013
Casitas B-lineage Lymphoma (CBL) linker region and Really Interesting New Gene (RING) finger mutations lead to enhanced Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) signaling via elevated levels of Janus Kinase 2 (JAK2) and Lck-Yes-related novel tyrosine kinase (LYN).
Mojib Javadi, Terri D. Richmond, Kai Huang, Dwayne L. Barber
First Published on May 21, 2013
An integrin-binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of IGF1R and suppresses tumorigenesis, while the mutant still binds to IGF1R
Masaaki Fujita, Katsuaki Ieguchi, Dora Cedano Prieto, Andrew Fong, Charles Wilkerson, Jane Q. Chen, Mac Wu, Su-Hao Lo, Anthony T. W. Cheung, Machelle D. Willson, Robert D. Cardiff, Alexander D. Borowsky, Yoko K. Takada, Yoshikazu Takada
First Published on May 21, 2013
Identification and functional characterization of a Ku-binding motif in Aprataxin Polynucleotide kinase/phosphatase-Like Factor (APLF)
Purnata Shirodkar, Amanda L. Fenton, Li Meng, Christine A. Koch
First Published on May 21, 2013
The Epac1 signaling pathway regulates Cl<-> secretion via modulation of apical KCNN4c channels in diarrhea
Irshad Ali Shiekh, Hemanta Koley, Manoj K. Chakrabarti, Kazi Mirajul Hoque
First Published on May 17, 2013
Phosphorylation Of Minichromosome Maintenance Protein 7 (MCM7) By Cyclin/Cdks Affected Its Function In Cell Cycle Regulation
Qian Wei, Junhui Li, Ting Liu, Xiaomei Tong, Xin Ye
First Published on May 17, 2013
Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β
Mitsuyoshi Motizuki, Kazunobu Isogaya, Kunio Miyake, Hiroaki Ikushima, Takeo Kubota, Kohei Miyazono, Masao Saitoh, Keiji Miyazawa
First Published on May 17, 2013
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Best of 2012

Ada Hang-Heng Wong, Chuangye Yan, Yigong Shi
Crystal Structure of the Yeast Metacaspase Yca1
August 24, 2012 The Journal of Biological Chemistry, 287, 29251-29259.

PAPERS OF THE WEEK

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AUTHOR PROFILES

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REPORTS

Analysis of Human Bronchial Epithelial Cell Proinflammatory Response to Burkholderia cenocepacia Infection
Devyn D. Gillette, Prexy A. Shah, Thomas Cremer, Mikhail A. Gavrilin, Beth Y. Besecker, Anasuya Sarkar, Daren L. Knoell, Estelle Cormet-Boyaka, Mark D. Wewers, Jonathan P. Butchar, Susheela Tridandapani
First Published on Dec 26, 2012
Microtubule-associated Protein/Microtubule Affinity-regulating Kinase 4 (MARK4) Is a Negative Regulator of the Mammalian Target of Rapamycin Complex 1 (mTORC1)
Li Li, Kun-Liang Guan
First Published on Nov 26, 2012
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CLASSICS

How the Glycine and GABA Receptors Were Purified
First Published on Nov 23, 2012
Blood Clotting and Coagulation Factors: The Work of Yale Nemerson
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jun 24, 2011
The Process of Reversible Phosphorylation: the Work of Edmond H. Fischer
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jan 14, 2011
The Waterfall Sequence for Blood Clotting: the Work of Earl W. Davie
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Nov 24, 2006
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REFLECTIONS

Wandering through the Laboratory
Philip W. Majerus
First Published on Dec 17, 2010
The Ribosome as a Conveying Thermal Ratchet Machine
Alexander S. Spirin
First Published on May 05, 2009
A Brief Historical Review of the Waterfall/Cascade of Blood Coagulation
Earl W. Davie
First Published on Oct 21, 2003
The Story of Glutamine Synthetase Regulation
Earl R. Stadtman
First Published on Oct 03, 2001
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MINIREVIEWS

Calcium Channels and Short-term Synaptic Plasticity
William A. Catterall, Karina Leal, Evanthia Nanou
First Published on Feb 11, 2013
Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling
Hsueh-Liang Fu, Rajeshwari R. Valiathan, Richard Arkwright, Anjum Sohail, Cosmin Mihai, Malika Kumarasiri, Kiran V. Mahasenan, Shahriar Mobashery, Paul Huang, Gunjan Agarwal, Rafael Fridman
First Published on Jan 18, 2013
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Most Read
Last Two Months

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Promotes Both Survival and Neuritogenesis in PC12 Cells Through Activation of Nuclear Factor κ B (NF-κB) Pathway* INVOLVEMENT OF EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK), CALCIUM AND c-REL".
Destiny-Love Manecka, Sardar Faisal Mahmood, Luca Grumolato, Isabelle Lihrmann, Youssef Anouar
First Published on Apr 05, 2013
Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase C epsilon regulates Ras/MAP kinase signaling and neuronal differentiation
Ana Lonic, Jason A. Powell, Yang Kong, Daniel Thomas, Jessica K. Holien, Nhan Truong, Michael W. Parker, Mark A. Guthridge
First Published on Apr 05, 2013
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MOST CITED

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Chunli Yu, Yan Chen, Gary W. Cline, Dongyan Zhang, Haihong Zong, Yanlin Wang, Raynald Bergeron, Jason K. Kim, Samuel W. Cushman, Gregory J. Cooney, Bronwyn Atcheson, Morris F. White, Edward W. Kraegen, Gerald I. Shulman
First Published on Nov 14, 2002
Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17
Sudeepta Aggarwal, Nico Ghilardi, Ming-Hong Xie, Frederic J. de Sauvage, Austin L. Gurney
First Published on Nov 04, 2002
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